archeal

Sequence analysis suggests that these features are conserved throughout all archeal receptors

PLoS ONE Alerts: New Articles Pascal F. Egea et al. 2008

These properties appear to be conserved in all archeal receptor sequences.

PLoS ONE Alerts: New Articles Pascal F. Egea et al. 2008

Pfu - SRP54 and SRP19 (in press in PloS One) have been incorporated into a model of the archeal SRP•SR targeting complex.

PLoS ONE Alerts: New Articles Pascal F. Egea et al. 2008

While the overall architecture of the archeal receptor resembles its previously described bacterial homologues from the SRP / SR GTPases family, the structure of

PLoS ONE Alerts: New Articles Pascal F. Egea et al. 2008

While FtsY and some other bacterial receptors possess an extra N-terminal A domain of variable size and sequence, most bacterial and archeal receptors are further streamlined and reduced to the strictly conserved NG core.

PLoS ONE Alerts: New Articles Pascal F. Egea et al. 2008

A functional archeal SRP is organized around two proteins, SRP19 and SRP54 that assemble on SRP RNA.

PLoS ONE Alerts: New Articles Pascal F. Egea et al. 2008

We have built a model of the core of the archeal targeting complex based on structures of the

PLoS ONE Alerts: New Articles Pascal F. Egea et al. 2008

The sequence of Pfu-FtsY is aligned against 12 FtsY sequences from archeons representative of all families constituting the archeal kingdom.

PLoS ONE Alerts: New Articles Pascal F. Egea et al. 2008

A model for the interaction between SRP and SR in the archeal and eukaryotic core of the targeting complex The targeting complex is formed when SRP interacts with its receptor (

PLoS ONE Alerts: New Articles Pascal F. Egea et al. 2008

Figure 4B), helix αN1 of the non-archeal homologues is bent, resulting in an N terminal extension that packs against the surface of the N / G domain including C terminal helix α7 (

PLoS ONE Alerts: New Articles Pascal F. Egea et al. 2008