Definitions

from Wiktionary, Creative Commons Attribution/Share-Alike License.

  • noun An anticoagulant.

Etymologies

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Examples

  • One problem with this is that fondaparinux is not approved in the U.S.for treatment of HIT only argatroban and lepirudin are.

    Should we consider HIT (heparin induced thrombocytopenia) in cases of DVT and PE?

  • One problem with this is that fondaparinux is not approved in the U.S.for treatment of HIT only argatroban and lepirudin are.

    Archive 2007-01-01

  • The study was a randomized, open-label, exploratory study comparing fixed-dose, SC desirudin vs. adjusted-dose, IV argatroban in 16 patients with clinically suspected HIT.

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  • In addition, there was the need for only one dose adjustment throughout the entire trial in patients randomized to desirudin, as compared to an average of 3.8 dose adjustments per patient in subjects randomized to IV argatroban.

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  • In addition, the cost of treatment with desirudin was about one-fifth the cost of treatment with argatroban.

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  • In the study, no thrombosis or major bleeds occurred in patients who received desirudin, and fewer dose adjustments were required for patients receiving desirudin compared with those receiving argatroban.

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  • The PREVENT-HIT study found that desirudin warrants further investigation as an alternative treatment for thrombosis prophylaxis in surgery patients with HIT. argatroban, the current standard of care.

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  • PREVENT-HIT is a randomized trial comparing fixed-dose, subcutaneous (SC) desirudin with adjusted-dose, intravenous (IV) argatroban in patients with clinically suspected heparin-induced thrombocytopenia (HIT).

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  • The cost of desirudin ($1,750) was about one-fifth the cost of argatroban ($8,250).

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  • Patients were randomized to desirudin 15 or 30 mg SC every 12 hours or IV argatroban in a 1: 1 ratio.

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