Definitions
from Wiktionary, Creative Commons Attribution/Share-Alike License.
- noun chemistry A
thiomalate with the addition ofgold .
Etymologies
from Wiktionary, Creative Commons Attribution/Share-Alike License
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Examples
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Mayo Clinic researchers, led by Alan Fields, Ph. D., chair of the Department of Cancer Biology and a co-author of this report, discovered aurothiomalate in 2006 by screening thousands of Food and Drug Administration-approved drugs for their ability to inhibit PKCi signaling.
PhysOrg.com - latest science and technology news stories 2010
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Based on findings to date, a phase II clinical trial is being planned to combine aurothiomalate with agents targeted at other molecules involved in cancer growth.
PhysOrg.com - latest science and technology news stories 2010
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It is possible that a future trial will test aurothiomalate in pancreatic cancer patients, she said.
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Dr. Murray stressed that this new study has not tested aurothiomalate against pancreatic cancer yet, but any treatment that targets this major cancer pathway offers a new avenue for therapy.
PhysOrg.com - latest science and technology news stories 2010
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A phase II trial being planned will combine aurothiomalate with drugs that target other molecules in these cancers, she noted.
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"When we put these cells into mice, we showed that not only did the tumors not grow very well, but they didn't metastasize well," she said. aurothiomalate (Myochrysine), which targets PKCi, could effectively treat pancreatic cancer alone or combined with other chemotherapy.
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It is possible that a future trial will test aurothiomalate in pancreatic cancer patients, she said.
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A phase II trial being planned will combine aurothiomalate with drugs that target other molecules in these cancers, she noted.
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"When we put these cells into mice, we showed that not only did the tumors not grow very well, but they didn't metastasize well," she said. aurothiomalate (Myochrysine), which targets PKCi, could effectively treat pancreatic cancer alone or combined with other chemotherapy.
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The data suggest that aurothiomalate, which targets PKCi, may be effective against pancreatic cancer either alone or in combination with other treatments, such as conventional chemotherapy.
PhysOrg.com - latest science and technology news stories 2010
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