autophosphorylation love

autophosphorylation

Definitions

from Wiktionary, Creative Commons Attribution/Share-Alike License.

  • noun biochemistry The phosphorylation of a kinase protein catalyzed by its own enzymatic activity

Etymologies

from Wiktionary, Creative Commons Attribution/Share-Alike License

From auto- +‎ phosphorylation

Examples

  • The finding of tyrosine-specific autophosphorylation of the receptor was a breakthrough in our understanding of how a signal from the outside reaches the inside of the cell.

    Physiology or Medicine 1986 - Press Release

  • Their intracellular domains though only 15% identical, show the presence of well conserved putative signalling motifs namely, 4 putative phosphorylation sites (3 Tyrosines and 1 Serine) two of which lie in a putative autophosphorylation domain, a PADVI motif of unknown function and a C terminal PDZ binding domain

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  • In vitro autophosphorylation of full length kinase (PknJ-FL) (2 µg) and phosphotransfer on 5 µg Myelin basic protein (MyBP).

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  • Further autophosphorylation activity of PknJ-KD was examined in time-dependent manner to assess its efficiency.

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  • PknJ is shown to possess autophosphorylation activity and is also found to be capable of carrying out phosphorylation on the artificial substrate myelin basic protein (MyBP).

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  • XA21/Ax21 binding is hypothesized to activate the non-RD kinase domain leading to XA21 autophosphorylation and/or transphosphorylation of downstream target proteins

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  • ATP binding activates receptor autophosphorylation at several tyrosine residues, which in turn, enables the receptor's kinase activity toward intracellular protein substrates

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  • These 2 phosphorylation sites are Tyr 810 and Tyr 814 that lie in the putative autophosphorylation domain.

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  • XA21/Ax21 binding is hypothesized to activate the non-RD kinase domain leading to XA21 autophosphorylation and/or transphosphorylation of downstream target proteins

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  • Tyr 810 and 814 lie in a putative autophosphorylation domain.

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