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- noun biochemistry Self-
ubiquitinationby an ubiquitinating enzyme, usually an E3 or E4 ubiquitin ligase. This activity can be direct, as in monoubiquitin of a lysine residue on the E3 or E4 itself, or indirect, through addition of ubiquitinto an existing polyubiquitin chain that is attached to the E3 or E4.
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