Definitions

from Wiktionary, Creative Commons Attribution/Share-Alike License.

  • noun A particular endothelin receptor antagonist.

Etymologies

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Examples

  • Endothelin antagonists such as oral avosentan are already available and are prescribed for patients with cardiovascular conditions.

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  • In addition, there were more deaths in the groups taking avosentan (21 and 17) than in the group taking placebo (12).

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  • While avosentan at either dose lowered patients 'urinary protein excretion by 40%-50%

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  • The results suggest that lower doses of avosentan may have a more favorable risk/benefit ratio for patients.

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  • Johannes Mann, MD (Schwabing General Hospital and KfH Kidney Centre, in Munchen, Germany) and his colleagues examined the effects of avosentan on proteinuria and kidney function in patients with type 2 diabetes and kidney disease through a multicenter, multinational, double-blind, controlled trial.

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  • The Avosentan ASCEND study enrolled 1392 patients already being treated for kidney disease and randomized them to receive avosentan 25 mg, avosentan 50 mg, or placebo.

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  • The drug avosentan substantially reduces urinary protein loss in people with type 2 diabetes and kidney disease, but the drug causes serious side effects, according to a study appearing in an upcoming issue of the

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  • Specifically, lower doses of avosentan may generate more positive results.

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  • The drug avosentan substantially reduces urinary protein loss in people with type 2 diabetes and kidney disease, but the drug causes serious side effects, according to a study appearing in an upcoming issue of the Journal of the American Society Nephrology (JASN).

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