Definitions
from Wiktionary, Creative Commons Attribution/Share-Alike License.
- noun A
cytidine analogue used in the treatment of myelodysplastic syndrome.
Etymologies
Sorry, no etymologies found.
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Examples
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years and older who failed treatment with at least one hypomethylating agent, such as azacitidine or decitabine.
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News) ("Cyclacel") announced today 1-year survival data from a Phase 2 randomized trial of oral sapacitabine capsules, a novel nucleoside analogue, in older patients with myelodysplastic syndromes (MDS) refractory to hypomethylating agents, such as azacitidine and decitabine.
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The Food and Drug Administration approved azacitidine in May 2004; the drug is now marketed as Vidaza.
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In the 1980s, as a young oncology fellow at Mount Sinai School of Medicine in New York, Lewis Silverman proposed testing azacitidine as an epigenetic drug — that is, at lower doses than is typical for traditional chemotherapy, where it still might be effective reversing silenced genes.
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Last year, the Food and Drug Administration approved the first epigenetic drug, azacitidine , which treats a form of leukemia by reactivating those genes.
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One of the drugs used in the study, azacitidine, had been tested on different cancers decades ago but was deemed too toxic to use.
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These researchers also used low doses of azacitidine, combined with a newer drug, etinostat.
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The first patient was treated in a phase II investigator-sponsored trial of lintuzumab in combination with Vidaza (azacitidine) for patients with myelodysplastic syndromes
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The first patient was treated in a phase II investigator-sponsored trial of lintuzumab in combination with Vidaza (azacitidine) for patients with myelodysplastic syndromes
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The first patient was treated in a phase II investigator-sponsored trial of lintuzumab in combination with Vidaza (azacitidine) for patients with myelodysplastic syndromes
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