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- noun Plural form of
Sorry, no etymologies found.
It is soluble in water, and the solution dissolves many metals (zinc, iron, &c.) with liberation of hydrogen and formation of salts (azoimides, azides or hydrazoates).
To apply click chemistry to glycans, she and her colleagues designed a ring-shaped molecule, called difluorinated cyclooctyne or DIFO, that reacts with azides rapidly at physiological temperatures without the need for a toxic catalyst.
Earlier work by Bertozzi and her group had shown that glycans can be metabolically labeled with azides - a functional group featuring three nitrogen atoms - via a reaction they devised, which they called the Staudinger ligation.
To apply their copper-free click chemistry to living mice, Bertozzi and her group delivered azides to the surfaces of target cells within the mice via a metabolic precursor, then labeled select glycans (those that bore corresponding azido sialic acids) by covalent reaction in vivo with a panel of cyclooctyne-FLAG peptide conjugates.
"This copper-free click reaction of azides and DIFO combines the biocompatibility of the Staudinger ligation with the fast reaction kinetics of click chemistry," Bertozzi says.