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Examples

  • This aberration was corroborated by interphase fluorescence in situ hybridization, using a chromosome 18 pericentromeric probe, in the basaloid epithelial component of 7 of 11 pilomatricomas, including the index case.

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  • The observation that the pro-survival role of p63 in the prostate basaloid iPrEC cells depends on FASN, prompted us to investigate a possible association between p63 and FASN expression in the developing prostate.

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  • (SCC9) and immortalized prostate basaloid epithelial cells (iPrEC) were utilized to investigate the molecular pathways that mediate p63 function in epithelial cells.

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  • FASN expression levels appeared to be highest in non-keratinizing poorly differentiated tumors with basaloid morphology that also expressed very high p63 levels.

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  • Of note, FASN expression was more intense in the non-keratinizing poorly differentiated tumors with basaloid morphology, where p63 was found to be positive in almost 100% of tumor cells (

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