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This aberration was corroborated by interphase fluorescence in situ hybridization, using a chromosome 18 pericentromeric probe, in the basaloid epithelial component of 7 of 11 pilomatricomas, including the index case.
The observation that the pro-survival role of p63 in the prostate basaloid iPrEC cells depends on FASN, prompted us to investigate a possible association between p63 and FASN expression in the developing prostate.
(SCC9) and immortalized prostate basaloid epithelial cells (iPrEC) were utilized to investigate the molecular pathways that mediate p63 function in epithelial cells.
FASN expression levels appeared to be highest in non-keratinizing poorly differentiated tumors with basaloid morphology that also expressed very high p63 levels.
Of note, FASN expression was more intense in the non-keratinizing poorly differentiated tumors with basaloid morphology, where p63 was found to be positive in almost 100% of tumor cells (