Definitions
Sorry, no definitions found. Check out and contribute to the discussion of this word!
Etymologies
Sorry, no etymologies found.
Support
Help support Wordnik (and make this page ad-free) by adopting the word bcr.
Examples
-
In any case, what he found was that treating two different leukemia and lymphoma cell lines with ascorbate at those concentrations before treating them with chemotherapeutic agents, including mechanistically dissimilar agents such as doxorubicin, which intercalates with DNA and causes DNA breaks; methotrexate, which inhibits folate metabolism; cisplatin, which crosslinks DNA; vincristine, which interferes with microtubule function; and imatinib mesylate (better known by its trade name of Gleevec), a selective inhibitor of the activity of a protein called bcr-abl, which is the oncogene that plays a central role in the development of chronic myelogenous leukemia (CML).
Adrian Monck 2008
-
She later demonstrated this region encoded an aberrantly regulated c - abl oncogene, a tyrosine kinase, fused with a normal gene that her group proposed naming bcr for "breakpoint cluster region."
ScienceBlogs Channel : Life Science Abel Pharmboy none@example.com 2010
-
She later demonstrated this region encoded an aberrantly regulated c - abl oncogene, a tyrosine kinase, fused with a normal gene that her group proposed naming bcr for "breakpoint cluster region."
-
She later demonstrated this region encoded an aberrantly regulated c - abl oncogene, a tyrosine kinase, fused with a normal gene that her group proposed naming bcr for "breakpoint cluster region."
ScienceBlogs Channel : Life Science Abel Pharmboy none@example.com 2010
-
She later demonstrated this region encoded an aberrantly regulated c - abl oncogene, a tyrosine kinase, fused with a normal gene that her group proposed naming bcr for "breakpoint cluster region."
ScienceBlogs Channel : Life Science Abel Pharmboy none@example.com 2010
-
She later demonstrated this region encoded an aberrantly regulated c - abl oncogene, a tyrosine kinase, fused with a normal gene that her group proposed naming bcr for "breakpoint cluster region."
-
She later demonstrated this region encoded an aberrantly regulated c - abl oncogene, a tyrosine kinase, fused with a normal gene that her group proposed naming bcr for "breakpoint cluster region."
-
She later demonstrated this region encoded an aberrantly regulated c - abl oncogene, a tyrosine kinase, fused with a normal gene that her group proposed naming bcr for "breakpoint cluster region."
ScienceBlogs Channel : Life Science Abel Pharmboy none@example.com 2010
-
She later demonstrated this region encoded an aberrantly regulated c - abl oncogene, a tyrosine kinase, fused with a normal gene that her group proposed naming bcr for "breakpoint cluster region."
-
The genes abl and bcr, located on different chromosomes, fuse and express a hybrid BCR-ABL enzyme that is always active; this hyperactive BCR-ABL drives the overproliferation of white blood cells that is the hallmark of chronic myelogenous leukemia (CML).
HHMI News 2009
Comments
Log in or sign up to get involved in the conversation. It's quick and easy.