Definitions

from Wiktionary, Creative Commons Attribution/Share-Alike License.

  • noun biochemistry A light-sensitive competitive antagonist of GABA receptors; it is used in the study of epilepsy

Etymologies

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Examples

  • Finally, they showed that this second reaction could be blocked by bicuculline.

    Alcohol and The Addictive Brain Kenneth Blum 1991

  • Finally, they showed that this second reaction could be blocked by bicuculline.

    Alcohol and The Addictive Brain Kenneth Blum 1991

  • The Daoust group first showed that calcium bis acetylhomotaurine, a GABA A receptor agonist, reduced alcohol craving, and that this effect could be blocked by the GABA antagonist bicuculline, restoring craving.

    Alcohol and The Addictive Brain Kenneth Blum 1991

  • The Daoust group first showed that calcium bis acetylhomotaurine, a GABA A receptor agonist, reduced alcohol craving, and that this effect could be blocked by the GABA antagonist bicuculline, restoring craving.

    Alcohol and The Addictive Brain Kenneth Blum 1991

  • We recently found that rats learn to selectively self-administer picrotoxin or bicuculline, another GABAA receptor antagonist, into the supramammillary nucleus (SuM), a posterior hypothalamic structure localized anterior to the ventral tegmental area.

    BioMed Central - Latest articles 2010

  • Uva L, Librizzi L, Wendling F, de Curtis M (2005) Propagation dynamics of epileptiform activity acutely induced by bicuculline in the hippocampal-parahippocampal region of the isolated Guinea pig brain.

    PLoS Biology: New Articles Marta Gómez-Gonzalo et al. 2010

  • The effect of DAMGO on the frequency and amplitude of mini EPSCs recorded from inspiratory XII MNs was assessed with whole-cell recordings made in the presence of bath-applied TTX (1 µM), strychnine (10 µM), and bicuculline (10 µM) to block action potentials and GABA and glycinergic IPSCs, respectively.

    PLoS ONE Alerts: New Articles Amanda R. Lorier et al. 2010

  • (D) A cumulative histogram for both ACSF (right) and bicuculline (left) perfused hippocampal slices.

    PLoS ONE Alerts: New Articles 2009

  • (D) A cumulative histogram for both ACSF (right) and bicuculline (left) perfused hippocampal slices.

    PLoS ONE Alerts: New Articles Alexander Garthe et al. 2009

  • A receptor antagonist bicuculline methiodide (20 µM) and NMDA receptor antagonist D-APV (50 µM).

    PLoS ONE Alerts: New Articles Fang-Yu Chang et al. 2009

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