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Examples
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That is, even if we knew these binding-site conversions to be feasible, would that give us any reason to think that the more profound conversions are feasible?
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By their math it would then take around 400 million years for the binding-site switch to prove its benefit (if it had one) by becoming fully established in the fruit fly population.
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We hypothesized that the 9O12. 2 epitope must, at least in part, overlap with the collagen binding-site on GPVI.
PLoS ONE Alerts: New Articles Julien Muzard et al. 2009
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Given target and background sets of promoters, EXPANDER performs statistical tests to identify TFs whose binding-site signatures are significantly over-represented in the target set relative to background (TF enrichment is indicated by p-value) [7].
PLoS ONE Alerts: New Articles Roy Blum et al. 2009
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Furthermore, returning to the first question, it seems that even humble binding-site conversions are typically beyond the reach of Darwinian evolution.
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By their math it would then take around 400 million years for the binding-site switch to prove its benefit (if it had one) by becoming fully established in the fruit fly population.
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We hypothesized that the 9O12. 2 epitope must, at least in part, overlap with the collagen binding-site on GPVI.
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PDZ domain binding-site positions that were subjected to mutagenesis are shown as spheres.
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Our extensive dataset based on phage-displayed random peptide libraries shows a clear correlation between binding-site identity and specificity.
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Each row represents one mutant, ordered by PDZ domain binding-site position (labeled to the right of each set of rows), and each column represents one ligand position.
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