Definitions
from Wiktionary, Creative Commons Attribution/Share-Alike License.
- noun biology The
metabolic activation ofxenobiotic compounds intoreactive ,toxic compounds
Etymologies
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Examples
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Blood leaving the liver is eventually distributed to all other areas of the body; however, much of the absorbed xenobiotic has undergone detoxication or bioactivation.
Biotransformation 2008
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There are two types of metabolism - detoxification and bioactivation.
Toxicity 2007
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To characterise whether some selective serotonin reuptake inhibitor (SSRI) antidepressants reduce tamoxifen's effectiveness by inhibiting its bioactivation by cytochrome P450 2D6 (CYP2D6).
Latest headlines from BMJ Kelly 2010
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To characterise whether some selective serotonin reuptake inhibitor (SSRI) antidepressants reduce tamoxifen's effectiveness by inhibiting its bioactivation by cytochrome P450 2D6 (CYP2D6).
Latest headlines from BMJ Kelly 2010
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Steinkellner H, Rabot S, Freywald C, et al. Effects of cruciferous vegetables and their constituents on drug metabolizing enzymes involved in the bioactivation of DNA-reactive dietary carcinogens.
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The cytochrome P450 (CYP) gene family catalyzes drug metabolism and bioactivation and is therefore relevant to drug development.
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2 The bioactivation of tamoxifen to endoxifen is mainly catalysed by the cytochrome P450 isoenzyme 2D6 (CYP2D6) .2
Latest headlines from BMJ Andersohn 2010
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