Definitions

from Wiktionary, Creative Commons Attribution/Share-Alike License

  • n. A coenzyme produced within the body, an oxidized degradation product of tetrahydrobiopterin. Defects in biopterin synthesis or regeneration can cause a form of hyperphenylalaninemia, and biopterin deficiency has been associated with dystonia and rabies.

Etymologies

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Examples

  • As the reproducibility of biopterin-dependent enzyme kinetics are greatly affected by the instability of the biopterin cofactor, 6-MPH

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  • As relatively few enzymes require biopterin for activity, the discovery of a biopterin-dependent enzyme raises the issue of the possible sources of biopterin for this enzyme.

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  • Indeed, human GTP cyclohydrolase, limiting in biopterin synthesis, has been found to be elevated in.

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  • The residues present in the active site that interact with the aromatic amino acid substrate and biopterin cofactor are highlighted with black triangles.

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  • T. gondii has been shown to encode a functional pterin-4a-carbinolamine dehydratase involved in recycling biopterin but dihydropterin reductase has not been detected

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  • T. gondii enzymes exhibited an absolute requirement for biopterin for activity using the stable tetrahydrobiopterin analog 6-MPH

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  • The residues that interact with the biopterin cofactor and amino acid substrates in the rat TyrH (tyrosine hydroxylase) sequence

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  • The presence or absence of a biopterin synthetic pathway and its recycling are currently under investigation (37,38).

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  • As the enzyme is secreted, the host may supply the biopterin cofactor.

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  • Wachter, H.; Werner, E.R.: Stimulation of human nitric oxide synthase by tetrahydro - biopterin and selective binding of the cofactor.

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