Definitions
from Wiktionary, Creative Commons Attribution/Share-Alike License
- n. A particular drug used in chemotherapy.
Etymologies
Sorry, no etymologies found.
Examples
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Kruger found that treating yeast and mammalian cells with a drug called bortezomib elevated the amount of available Hsp70 and rescued mutant proteins.
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But that may not be wise if you are being treated for certain types of blood cancer with bortezomib, which is sold under the brand name Velcade.
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Background material for the study notes that some drugs, such as bortezomib, which now treat other cancers, may even have that capability, and an early-stage clinical trial using bortezomib for glioblastoma is currently taking place at Northwestern.
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The progression-free survival of 12.6 months is considered long compared to other targeted agents used in a similar population such as bortezomib (Velcade (R)) where the median time to progression was reported at 7.9 months.
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Blocking the proteolytic activity of the proteasome by either pharmacological inhibitors such as bortezomib / PS-341 or by polyglutamine repeat containing polypeptides severely compromises ERAD, induces accumulation of misfolded proteins within the ER lumen and imposes ER stress
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The potential use of Curaxins as adjuvants to cancer therapies inducing proteotoxic stress, such as bortezomib (Velcade�) or thermotherapy, opens a whole new avenue of potential treatment options that may broaden the spectrum of responding tumors by cutting off an escape mechanism.
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This website also details the role of such drugs as Avastin and bortezomib.
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Many of the proteins which are associated with multiple myeloma are known client proteins of Hsp90 and following treatment with bortezomib, Hsp90 related proteins are known to increase as a mechanism of resistance.
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The Phase 1, open-label, multi-center trial is designed to study ganetespib, bortezomib and dexamethasone in patients with relapsed/refractory multiple myeloma.
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Phase 1 trial evaluating ganetespib as a single agent and in combination with the proteasome inhibitor bortezomib for the treatment of relapsed multiple myeloma.
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