from The Century Dictionary.
- noun Disorder of the brain; insanity.
Sorry, no etymologies found.
The labors of a lifetime were concentrated on a few dazzling results: the long tedium of the means, the painful training, the hard mathematical preparation, the brain-sickness and heart-sickness of these years of solitude were quietly ignored.
It was all sheer brain-sickness, and lack of sleep, but at the moment it was horribly real.