Definitions
from Wiktionary, Creative Commons Attribution/Share-Alike License
- n. A non-selective beta blocker drug with additional weak alpha-blocking properties and some intrinsic sympathomimetic activity.
Etymologies
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Examples
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Another drug close to being resurrected is bucindolol, which had been sidelined by other pharmaceutical companies when research on similar cardiovascular medicines appeared to show more promise.
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Dr. Bristow and his colleague Stephen Liggett have since identified one gene variant that improves patients 'response to bucindolol and another that is linked with heightened risk of side effects, according to Dr. Bristow, chief science and medical officer.
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Laboratory Corp. of America of Burlington, N.C., is developing a genetic test in conjunction with bucindolol, ARCA said.
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Researchers said Monday that heart-failure patients with a favorable genetic variation who were given the drug bucindolol were 38% less likely to die from any cause than those given a placebo, when followed for an average of two years.
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Clyde Yancy, a heart-failure expert at Baylor College of Medicine not involved in the study, called the findings "incredibly intriguing," but cautioned that challenges remain both in gaining approval for bucindolol and determining how a drug linked to a genetic test will be incorporated into medical practice.
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ARCA says bucindolol would be the first drug for cardiovascular disease to be approved based on such tests.
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Closely held ARCA biopharma Inc. of Broomfield, Colo., which funded the study, holds rights to the drug and has filed for Food and Drug Administration approval to sell bucindolol to patients who take a gene test showing the likelihood that it will help.
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Those given bucindolol were also 48% less likely to die of heart-related causes and 44% less likely to be hospitalized for heart failure.
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TM bucindolol hydrochloride, is an investigational, pharmacologically unique beta-blocker and mild vasodilator being developed for heart failure.
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Patent and Trademark Office (USPTO) on methods of treating heart failure patients with bucindolol based on genetic testing.
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