Definitions
from Wiktionary, Creative Commons Attribution/Share-Alike License.
- noun A non-selective
beta blocker drug with additional weak alpha-blocking properties and someintrinsic sympathomimetic activity.
Etymologies
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Examples
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Researchers said Monday that heart-failure patients with a favorable genetic variation who were given the drug bucindolol were 38% less likely to die from any cause than those given a placebo, when followed for an average of two years.
Gene Analysis Boosts 2008
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Clyde Yancy, a heart-failure expert at Baylor College of Medicine not involved in the study, called the findings "incredibly intriguing," but cautioned that challenges remain both in gaining approval for bucindolol and determining how a drug linked to a genetic test will be incorporated into medical practice.
Gene Analysis Boosts 2008
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Dr. Bristow and his colleague Stephen Liggett have since identified one gene variant that improves patients 'response to bucindolol and another that is linked with heightened risk of side effects, according to Dr. Bristow, chief science and medical officer.
Genetics May Bring 2008
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Those given bucindolol were also 48% less likely to die of heart-related causes and 44% less likely to be hospitalized for heart failure.
Gene Analysis Boosts 2008
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ARCA says bucindolol would be the first drug for cardiovascular disease to be approved based on such tests.
Gene Analysis Boosts 2008
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Another drug close to being resurrected is bucindolol, which had been sidelined by other pharmaceutical companies when research on similar cardiovascular medicines appeared to show more promise.
Genetics May Bring 2008
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Laboratory Corp. of America of Burlington, N.C., is developing a genetic test in conjunction with bucindolol, ARCA said.
Gene Analysis Boosts 2008
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Closely held ARCA biopharma Inc. of Broomfield, Colo., which funded the study, holds rights to the drug and has filed for Food and Drug Administration approval to sell bucindolol to patients who take a gene test showing the likelihood that it will help.
Gene Analysis Boosts 2008
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TM bucindolol hydrochloride, is an investigational, pharmacologically unique beta-blocker and mild vasodilator being developed for heart failure.
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Patent and Trademark Office (USPTO) on methods of treating heart failure patients with bucindolol based on genetic testing.
THE MEDICAL NEWS Editors 2010
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