from The American Heritage® Dictionary of the English Language, 4th Edition

  • n. A drug administered orally in the treatment of depression and as an aid in the cessation of tobacco smoking, thought to inhibit neuronal uptake of serotonin, norepinephrine, and dopamine in the central nervous system.

from Wiktionary, Creative Commons Attribution/Share-Alike License

  • n. An aminoketone antidepressant that acts as a norepinephrine and dopamine reuptake inhibitor and nicotinic antagonist.


from The American Heritage® Dictionary of the English Language, 4th Edition

bu(tyl) + propi(ophen)on(e), a ketone (propio(nic acid) + phen(yl) + -one).


  • While some antidepressants actually increase weight, at least one—called bupropion (Wellbutrin)—has been shown to be effective for weight loss by influencing levels of norepinephrine (the fight-or-flight neurochemical), as well as increasing the pleasure-seeking dopamine.

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  • These may include small doses of antidepressants such as bupropion (Wellbutrin), paroxetine (Paxil), venlafaxine (Effexor), and fluoxetine (Prozac), or clonidine, which is normally used to control high blood pressure.

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  • The fast metabolizers do better with drug therapy, such as bupropion (Zyban), as compared with the patch. - latest science and technology news stories

  • If you're currently being treated with an antidepressant, ask your prescribing doctor about switching to a class of drugs less associated with sexual side effects, such as bupropion, sold as Wellbutrin. - Local News

  • This, even though anti-tobacco drugs - such as bupropion and varenicline - and NRT products like patches, gum and lozenges have been in the market for more than 25 years.

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  • Interventions that involved the use of medications, such as bupropion (Wellbutrin, an antidepressant), fluoxetine (

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  • Another 11.2% and 3.2% used varenicline and bupropion, respectively, which don't contain nicotine.

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  • Dr. Robert Kushner, for example, whom I respect, very reasonably points out that the two drugs combined in Contrave -- bupropion and naltrexone -- are already in widespread use.

    David Katz, M.D.: Questioning Weight Loss Drugs

  • Among other anti-obesity drugs in clinical trials the Contrave from Orexigen is a combination of bupropion, a dopamine and norepinephrine reuptake inhibitor, with naltrexone, an opioid antagonist used to treat various addictive disorders [6].

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  • Generic bupropion (Wellbutrin is the more expensive brand name).

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