c-Src

More of these kinds of drugs are being developed, targeting oncogenes such as c-Myc and c-Src.

That's another fine mess you've made Jonathan! - The Panda's Thumb 2005

In another set, 16 specimens of MM, 16 SCCs and 16 BCCs were analyzed for the expression of c-Src and c-Yes using immunohistochemical staining.

BioMed Central - Latest articles Jang Hyun Lee 2010

Among the SFKs, c-Src and c-Yes are particularly over-expressed or hyper-activated in many human epithelial cancers.

BioMed Central - Latest articles Jang Hyun Lee 2010

Objectives: To investigate the expression of c-Src and c-Yes in cutaneous carcinomas to include malignant melanoma (MM), squamous cell carcinoma (SCC) and basal cell carcinoma (BCC).

BioMed Central - Latest articles Jang Hyun Lee 2010

Immunohistochemical staining results of c-Src and c-Yes in MM, SCC, and BCC mirrored those of the western blot analysis.

BioMed Central - Latest articles Jang Hyun Lee 2010

Western blotting showed that c-Src was expressed in all malignant skin tumors, but not in normal skin, while c-Yes was expressed in MM and SCC, but not in BCC and normal skin.

BioMed Central - Latest articles Jang Hyun Lee 2010

Conclusions c-Src, rather than c-Yes, plays a key role in the proliferation and progression of malignant skin cancers.

BioMed Central - Latest articles Jang Hyun Lee 2010

We examined 6 normal skin tissues and 18 malignant skin tumor tissues using western blotting for the expression of c-Src and c-Yes.

BioMed Central - Latest articles Jang Hyun Lee 2010

Furthermore, co-immunoprecipitation assays showed that c-Src interacts with Akt in response to ghrelin allowing the phosphorylation of Akt at Y residue (s).

PLoS ONE Alerts: New Articles 2009

Because c-Src contains an SH3 domain, it was proposed that Src interacts with the PXXP motif of Akt

PLoS ONE Alerts: New Articles 2009