from Wiktionary, Creative Commons Attribution/Share-Alike License

  • n. A protein phosphatase that stimulates the growth and differentiation of T cells


Sorry, no etymologies found.


  • Elidel belongs to a class of drugs known as calcineurin inhibitors, so called because they reduce immune activity by inhibiting the activity of the enzyme calcineurin.

    FDA Runs Protection Racket For Big Pharma

  • AKAP5 protein domains that interact with other signaling molecules, such as calcineurin, have been mapped to regions still present in the D36 protein

    PLoS ONE Alerts: New Articles

  • This is of clinical relevance because cyclosporine A is a known inhibitor of calcineurin.

    Urology Division Research

  • In time, a slow and steady rise in basal cell calcium levels leads to activation of calcineurin, which in turn leads to nuclear importation of the transcription factor NFAT (Nuclear Factor of T-cells).

    Urology Division Research

  • In addition to undergoing hypertrophy, these mouse bladders also show signs of activation of the calcineurin NFAT pathway and shifts in their expression of myosin heavy chain isoforms.

    Urology Division Research

  • Prior to the approval of Elidel for treating skin conditions in children over 2 years of age, calcineurin inhibitors were used as systemic immunosuppressants in organ transplant patients.

    FDA Runs Protection Racket For Big Pharma

  • On February 15, 2005, an FDA advisory committee met to discuss calcineurin inhibitors.

    FDA Runs Protection Racket For Big Pharma

  • When this protein is activated, it and another protein, calcineurin, trigger the physical changes that muscle cells undergo after intense exercise.

    Boing Boing: April 7, 2002 - April 13, 2002 Archives

  • It works by intervention of a phosphorylation reaction - it inactivates the phosphatase calcineurin.

    Physiology or Medicine 1992 - Press Release

  • Belatacept is different from calcineurin inhibitors (CNI), such as cyclosporine, which is the class of drugs most commonly used to suppress the immune system in transplant patients, because it does not cause the toxicities associated with CNI - such as nephrotoxicity and aggravating cardiovascular risk factors.

    EurekAlert! - Breaking News


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