Definitions

from Wiktionary, Creative Commons Attribution/Share-Alike License

  • n. Plural form of calpain.

Etymologies

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Examples

  • Enzymes called calpains mainly weaken the supporting proteins that hold the contracting filaments in place.

    On Food and Cooking, The Science and Lore of the Kitchen

  • Overactivation of proteins known as calpains, which are involved in memory formation, has been linked to Alzheimer disease.

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  • The calpains begin to denature and lose activity around 105°F/40°C, the cathep-sins around 122°F/50°C.

    On Food and Cooking, The Science and Lore of the Kitchen

  • Since calpains, a group of calcium activated proteases, play a key role in GAD65/67 cleavage under excitotoxic conditions the results suggest that GADs are cleaved after ubiquitination and degradation of an unknown binding partner by the proteasome.

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  • CB CD34+ cells were expanded with cytokines in the presence or absence of cell permeable inhibitors of caspases and calpains; zVADfmk and zLLYfmk respectively.

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  • This broad embrace also guarantees that calpastatin will precisely recognize only calpains, rather than mistakenly attach to other similar enzymes in the cell.

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  • As the cell's molecular overachievers, calpains function in many cellular processes, including the movement of cells in tissues, the death of damaged cells, insulin secretion, and brain cell and muscle function.

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  • The downside of this broad set of responsibilities is that defective or overactive calpains have been linked to an array of disorders, including a form of muscular dystrophy, Type 2 diabetes, gastric cancers, Alzheimer's and Parkinson's diseases, cataracts, and the death of both heart muscle in heart attacks and of brain tissue in stroke and traumatic brain injury.

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  • Scientists at St. Jude have gained new insights into regulation of one of the body's enzyme workhorses called calpains.

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  • Scientists at St. Jude Children's Research Hospital have gained new insights into regulation of one of the body's enzyme workhorses called calpains.

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