Definitions
from Wiktionary, Creative Commons Attribution/Share-Alike License.
- noun biochemistry A
protein (with a correspondinggene of the same name) that is anendogenous calpain inhibitor
Etymologies
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Examples
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"Previous studies on calpastatin had revealed how a few of the parts of the calpastatin molecule attach to calpain in the inhibition process," said Green, the report's senior author.
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A central question has been how calpastatin is so exquisitely specific in attaching to calpain and inhibiting it-essentially ignoring other highly similar enzymes in the cell.
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"Calpain has multiple domains, and what we saw was that calpastatin wraps itself around pretty much every domain of calpain," said Moldoveanu, the report's first author.
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Nature, Green and his colleagues report new information on the specificity of calpastatin.
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This broad embrace also guarantees that calpastatin will precisely recognize only calpains, rather than mistakenly attach to other similar enzymes in the cell.
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Furthermore, the researchers discovered how calpastatin evades being chewed up by calpain.
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"However, there was no overall picture of calpastatin that revealed how it was so precise in its attachment and potent in its function."
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Furthermore, the researchers discovered how calpastatin evades being chewed up by calpain.
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"This new structural information on calpastatin and on calpain's conformational changes not only explains a lot about calpain's regulation," Green said.
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The structural picture obtained of the two proteins clutched together clearly revealed why calpastatin so specifically attaches to calpain.
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