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- n. Plural form of camptothecin.
Sorry, no etymologies found.
Understanding Top1 also is clinically important, because the enzyme is the target of anti-cancer drugs called camptothecins, which prevent Top1 from resealing the nicked DNA, keeping the replication machinery from working, and killing proliferating cancer cells.
Most cytotoxic agents bind DNA's major groove, have little sequence-specificity, and are severely toxic to normal tissues (including topoisomerase inhibitors, such as camptothecins and anthracyclines).
Moreover, Recql5 expression was recently shown to be an important determinant in sensitivity to camptothecins, a class of anticancer drugs that are currently used to treat human colon cancer patients.
Bjornsti said the findings might lead to the design of anti-cancer drugs that trap Top1 in a different way from camptothecins.
Pommier Y (2006) Topoisomerase I inhibitors: camptothecins and beyond.
Since the success of camptothecins has already shown that Top1 is a valid target for anti-cancer drugs, the prospect of finding a whole new way of targeting the same enzyme is very exciting. "