Definitions

from Wiktionary, Creative Commons Attribution/Share-Alike License

  • n. Plural form of camptothecin.

Etymologies

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Examples

  • Understanding Top1 also is clinically important, because the enzyme is the target of anti-cancer drugs called camptothecins, which prevent Top1 from resealing the nicked DNA, keeping the replication machinery from working, and killing proliferating cancer cells.

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  • Most cytotoxic agents bind DNA's major groove, have little sequence-specificity, and are severely toxic to normal tissues (including topoisomerase inhibitors, such as camptothecins and anthracyclines).

    RedOrbit News - Technology

  • Moreover, Recql5 expression was recently shown to be an important determinant in sensitivity to camptothecins, a class of anticancer drugs that are currently used to treat human colon cancer patients.

    Medlogs - Recent stories

  • Bjornsti said the findings might lead to the design of anti-cancer drugs that trap Top1 in a different way from camptothecins.

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  • Pommier Y (2006) Topoisomerase I inhibitors: camptothecins and beyond.

    PLoS ONE Alerts: New Articles

  • Since the success of camptothecins has already shown that Top1 is a valid target for anti-cancer drugs, the prospect of finding a whole new way of targeting the same enzyme is very exciting. "

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