Definitions
from The American Heritage® Dictionary of the English Language, 4th Edition
- n. An antibiotic derived from a bacterium (Streptomyces capreolus) that is effective against the microorganism responsible for tuberculosis in humans.
from Wiktionary, Creative Commons Attribution/Share-Alike License
- n. A peptide antibiotic, commonly grouped with the aminoglycosides, given in combination with other antibiotics for tuberculosis.
Etymologies
Examples
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Aspen currently manufactures the oral TB drug cycloserine and within about 15 months will be able to manufacture capreomycin, thanks to Lilly's assistance, said Aspen executive director Stavros
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"Accordingly, the new agreed-upon definition of XDR-TB is the occurrence of TB in persons whose M. tuberculosis isolates are resistant to isoniazid and rifampin plus resistant to any fluoroquinolone and at least one of three injectable second-line drugs (i.e. amikacin, kanamycin, or capreomycin)."
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XDR-TB bacteria are resistant to first line therapies, including isoniazid and rifampicin, any fluoroquinolone and at least one of three injectable second-line drugs capreomycin, kanamycin, and amikacin.
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Using technology called X-ray crystallography, Steitzand his team describe where the antibiotics viomycin and capreomycin bind - at a site between the large and small subunits of the ribosome.
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The structures of the anti-tuberculosis antibiotics viomycin and capreomycin bound to the 70S ribosome
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Aspen said on Tuesday Eli Lilly would transfer its technology to Aspen for the production of two drugs that include capreomycin -- one of the few key treatment options for patients with multi-drug-resistant TB (MDR-TB).
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Slide 11: Medications: Primary Agents Secondary Agents isoniazid* capreomycin ethambutol cycloserine pyrazinamide (PZA) ethionamide rifampin kanamycin Streptomycin para-aminosalicyclic acid (PSA) * most frequently used 01 / 01 / 09 11 www. healthnursesdoctors.com
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MSF calculation on the basis of Green Light Committee prices for a patient weighing 50kg for a regimen of pyrazinamide, prothionamide, levofloxacin, cycloserine and capreomycin as an injectable.
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An alternative to kanamycin that is administered by a painful daily injection, capreomycin can provoke potentially allergic reactions.
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- Meanwhile, six medical experts from the universities of Stellenbosch and Cape Town wrote last month that a class of antibiotic called aminoglycosides and capreomycin were effective in treating MDR-TB, but these drugs had known dose-related adverse effects.
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