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Examples
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In our attempt to obtain further in vivo evidence of caspase-4 down-regulation mediated by an FE65 / Teashirt complex, we encountered the difficulty that the
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A subsequent step evaluated the interactions of FE65 with Teashirt1, Teashirt2, and Teashirt3 gene expression for predicting caspase-4 expression.
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In contrast, caspase-4 expression was significantly elevated in subjects with definite or probable AD, as compared to control subjects (F Fig. 7A).
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It was of great interest to note that for both SNPs, the AD risk allele was associated with decreased Teashirt3 expression, which, based on our cell biological and postmortem studies, we would predict would lead to increased expression of caspase-4. ultrabithorax [27], none of which are represented in the human or mouse genomes.
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B, Altered expression of FE65, caspase-4 and Teashirt gene products as a function of CDR score.
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Relative caspase-4 expression (expressed as the ratio of caspase-4 expression in clone 12 relative to expression in clone 1) was significantly increased when siRNA for either FE65 or Teashirt3 were introduced into clone 12, and the repression was almost completely abolished when both siRNAs were simultaneously introduced, confirming that the reduced expression of caspase-4 observed upon overexpression of FE65 and Teashirt3 was mediated by these proteins.
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Extracts from indicated cell lines were subjected to qPCR followed by normalization of caspase-4 expression to that of control genes using qBase (version 1.3.5).
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In AD, this relationship breaks down indicating that other factors associated with disease progression (including perhaps cellular changes) have important effects on the expression of caspase-4.
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Analysis of the interaction of FE65 and Teashirt expression with caspase-4 expression.
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A, Altered expression of FE65, caspase-4 and Teashirt gene products in AD.
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