Definitions

from The American Heritage® Dictionary of the English Language, 4th Edition

  • n. Any of various proteolytic enzymes found in animal tissue that catalyze the hydrolysis of proteins into polypeptides.

from Wiktionary, Creative Commons Attribution/Share-Alike License

  • n. Any of a family of proteases primarily active within lysosomes.

Etymologies

German Kathepsin, from Greek kathepsein, to digest : kat-, kata-, cata- + hepsein, to boil.
(American Heritage® Dictionary of the English Language, Fourth Edition)
From the German Kathepsin, derived from Ancient Greek καθέψω (kathépsō, "boil down"). (Wiktionary)

Examples

  • Santora said odanacatib works by inhibiting an enzyme called cathepsin K.

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  • Instead, the chloroquine molecule appears to block the action of a key enzyme, called cathepsin L, which is essential to the virus's growth and maturation.

    EurekAlert! - Breaking News

  • SAN DIEGO--(BUSINESS WIRE)-- New clinical and pre-clinical data on Merck's odanacatib, an investigational cathepsin K (cat-K) inhibitor for the treatment of osteoporosis in post-menopausal women, were presented at the 33

  • Abstract # 1030; Oral Session 05: New Approaches to Osteoporosis Treatment Preclinical, September 17, 2011, 10:45 - 11:00 AM PT - Efficacy of the combination regimens of the cathepsin K inhibitor odanacatib versus alendronate with parathyroid hormone in estrogen-deficient rabbits

  • Odanacatib selectively inhibits cathepsin K, the major enzyme in osteoclasts that is responsible for the breakdown of existing bone tissue.

  • Medivir presented preclinical data from its cathepsin K inhibitor program at the ASBMR meeting

    THE MEDICAL NEWS

  • Boudreau F, Lussier CR, Mongrain S, Darsigny M, Drouin JL, et al. (2007) Loss of cathepsin L activity promotes claudin-1 overexpression and intestinal neoplasia.

    PLoS ONE Alerts: New Articles

  • RNAi; MMP-9; uPAR; cathepsin; prostate cancer; apoptosis

    Naturejobs - All Jobs

  • In this study, the therapeutic potential of siRNA-mediated targeting of matrix metalloproteinase-9 (MMP-9), urokinase plasminogen activator receptor (uPAR), and cathepsin B

    Naturejobs - All Jobs

  • Drs. Johanna Joyce, Douglas Hanahan and colleagues lend new insight into how broad-spectrum cysteine cathepsin inhibitors combat pancreatic cancer, and provide new data to help ... read more

    Selective inhibition of BMK1 suppresses tumor growth

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