Definitions

from Wiktionary, Creative Commons Attribution/Share-Alike License

  • n. Any of a family of proteins associated with caveolae membranes

Etymologies

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Examples

  • (PHILADELPHIA) Reporting online in the American Journal of Pathology, researchers from the Kimmel Cancer Center at Jefferson have implicated the loss of a stromal protein called caveolin-1 as a major new prognostic factor in patients with breast cancer, predicting early disease recurrence, metastasis and breast cancer patient survival.

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  • Reporting online in the American Journal of Pathology, researchers from the Kimmel Cancer Center at Jefferson have implicated the loss of a stromal protein called caveolin-1 as a major new prognostic factor in patients with breast cancer, predicting early disease recurrence, metastasis and breast cancer patient survival.

    Emaxhealth

  • Exposure to larger pores induced genes involved with cytoskeleton elements such as villin, myosin, cofilin, and caveolin that play an important role in cell morphology.

    Nanotechnology is Key to Next-generation Tissue | Impact Lab

  • Phosphoinositide 3-kinase (PI3K) localization to lipid rafts was confirmed using PI3K and anti-caveolin-1 antibodies.

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  • The role of lipid rafts was assessed by cholesterol depletion and caveolin colocalization.

    BioMed Central - Latest articles

  • Expression of a peptide corresponding to the caveolin 1 scaffolding domain is sufficient to inhibit TrxR activity.

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  • We also show that overexpression of caveolin 1 inhibits TrxR activity, whereas a lack of caveolin 1 activates TrxR, both in vitro and in vivo.

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  • Inhibition of thioredoxin reductase 1 by caveolin 1 promotes stress-induced premature senescence

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  • We show that caveolin 1, the structural protein component of caveolae, is a TrxR1-binding protein by demonstrating that the scaffolding domain of caveolin 1 (amino acids 82-101) binds directly to the caveolin-binding motif (CBM) of TrxR1

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  • A TrxR1 mutant lacking the CBM, which fails to localize to caveolae and bind to caveolin 1, is constitutively active and inhibits oxidative-stress-mediated activation of the p53/p21

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