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Examples
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This nano-shuttle system is believed to activate an albumin-specific (Gp60) receptor-mediated transcytosis path through the cell wall of proliferating tumor cells, using caveolin-1 activated caveolar transport.
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This nano-shuttle system is believed to activate an albumin-specific (Gp60) receptor-mediated transcytosis path through the cell wall of proliferating tumor cells, using caveolin-1 activated caveolar transport.
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The absence of stromal caveolin-1 was strongly associated with other predictors of more aggressive disease, such as higher tumor stage and lymph node metastasis.
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The prognostic value of a loss of caveolin-1 has now been validated in three independent patient populations.
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When cancer cells arise, the fibroblasts stop making caveolin-1.
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In lymph-node positive patients, the difference in PFS was especially pronounced: The approximate five-year survival rate for patients positive for stromal caveolin-1 was 80 percent, vs. 7 percent for patients negative for stromal caveolin-1.
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They used three tissue cores from each patient tumor sample, and analyzed each core for stromal caveolin-1 using immunohistochemistry staining.
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Among each subgroup of patients - grouped by prognostic factors such as hormone status, disease stage or lymph node status - a loss of stromal caveolin-1 remained the single strongest predictor of breast cancer patient outcome.
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In an additional study, published online in Cancer Biology & Therapy, the researchers also found that the loss of stromal caveolin-1 in ER-positive non-invasive breast cancers called ductal carcinoma in situ (DCIS) serves as a biomarker for progression to invasive breast cancer.
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(PHILADELPHIA) Reporting online in the American Journal of Pathology, researchers from the Kimmel Cancer Center at Jefferson have implicated the loss of a stromal protein called caveolin-1 as a major new prognostic factor in patients with breast cancer, predicting early disease recurrence, metastasis and breast cancer patient survival.
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