cdk2

Oakes V, Beamish H, Giles N, Stevens F, et al. (2008) Cyclin A / cdk2 coordinates centrosomal and nuclear mitotic events.

PLoS ONE Alerts: New Articles Katherine Drews-Elger et al. 2009

E2F4 and E2F5 in complexes with pocket proteins p107 or p130 stop cells in G1, repressing transcription of genes important for cell cycle progression. p107 and p130 inhibits activity of cyclin / cdk2 complexes.

BioMed Central - Latest articles Piotr Poplawski and Alicja Nauman 2008

Overexpression of cyclin D1 and cdk4 also affects later events in the FGF response The maintenance of FGF-induced growth arrest is characterized by the accumulation of hypophosphorylated p130 by 10-16 hrs of FGF treatment, that follows a dramatic drop in cyclin E / cdk2 activity between 6 and 12 hrs

PLoS ONE Alerts: New Articles Victoria Kolupaeva et al. 2008

The cyclin E / cdk2 and cyclin A / cdk 2 complexes were isolated using anti-cyclin E and anti-cyclin A antibodies and histone H1 was used as a substrate.

PLoS ONE Alerts: New Articles Victoria Kolupaeva et al. 2008

Preventing p107 dephosphorylation in FGF-treated cells, whether by overexpression of a p107 kinase or by inactivation of the PP2A phosphatase, also prevents FGF-induced cell cycle arrest, dephosphorylation of p130, and downregulation of cyclin E / cdk2 and cyclin A / cdk2 activity.

PLoS ONE Alerts: New Articles Victoria Kolupaeva et al. 2008

CyclinD / cdk4-expressing RCS cells became resistant to FGF-induced p107 dephosphorylation and growth arrest, and maintained significantly high levels of cyclin E / cdk2 activity and of phosphorylated p130 at later times of FGF treatment.

PLoS ONE Alerts: New Articles Victoria Kolupaeva et al. 2008

Additionally, the overexpressed cyclin D1 and cdk4 could sequester p21 and p27, therefore reducing the repression of the cyclin E / cdk2 activity by these kinase inhibitors.

PLoS ONE Alerts: New Articles Victoria Kolupaeva et al. 2008

(G) 20 µg of total protein were analyzed by WB, with antibodies against cdk2 or p21.

PLoS ONE Alerts: New Articles Victoria Kolupaeva et al. 2008

[11], which is induced in S phase slightly later than cyclin E, we tested the activity of cyclin A / cdk2 complexes.

PLoS ONE Alerts: New Articles Victoria Kolupaeva et al. 2008