channelrhodopsin love

channelrhodopsin

Definitions

from Wiktionary, Creative Commons Attribution/Share-Alike License

  • n. An opsin protein that controls phototaxis in unicellular green algae.

Etymologies

from Wiktionary, Creative Commons Attribution/Share-Alike License

channel +‎ rhodopsin

Examples

  • But even if those succeed, introducing a protein like channelrhodopsin from a nonmammal species could set off a dangerous immune reaction in humans, warned Dr. Howard Federoff, a neuroscientist at Georgetown University and chairman of the National Institutes of Health committee that reviews all gene-therapy clinical trial protocols in the United States.

    The Beam that Flips the Switch for Autistism | Impact Lab

  • The researchers used a molecular "switch" from green algae called channelrhodopsin-2 (ChR2), which is turned on by blue light.

    PhysOrg.com - latest science and technology news stories

  • In a study in 2005, Ed Boyden at the Massachusetts Institute of Technology infected neurons in Petri dishes with viruses carrying the ChR2 gene, which codes for a light-sensitive protein called channelrhodopsin-2.

    dailyindia.com News Feed

  • He found a bacterial gene, halorhodopsin, that had properties suggesting it could do the opposite of channelrhodopsin.

    World Wide Mind

  • Genes like green fluorescent protein GFP and channelrhodopsin can be given a control element so that they only act if c-fos protein is present.

    World Wide Mind

  • Whereas channelrhodopsin makes a neuron fire, GFP shows you that it has fired.

    World Wide Mind

  • Then, shining blue light on the tissue immediately afterward will activate the channelrhodopsin gene in those same neurons, and only in those neurons.

    World Wide Mind

  • In 2003 they published a paper with a bold claim: “ChR2 [a variant of channelrhodopsin] may be used to depolarize [that is, excite] animal cells… simply by illumination.”

    World Wide Mind

  • If they wanted channelrhodopsin to work only in, say, parvalbumin-positive fast-spiking interneurons, they could use the promoter for that cell type.

    World Wide Mind

  • By inserting channelrhodopsin and GFP genes into a neuron, one can make it fire at will and visually confirm that it has fired, simply by shining light of various wavelengths at it through a fiber-optic cable.

    World Wide Mind

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