Definitions
from the GNU version of the Collaborative International Dictionary of English.
- noun (Chem.) An alkaloidal principle obtained from the celandine, and named from the red color of its salts. It is a colorless crystalline substance, and acts as an acrid narcotic poison. It is identical with
sanguinarine .
from Wiktionary, Creative Commons Attribution/Share-Alike License.
- noun A
benzophenanthridine alkaloid extracted from thegreater celandine (Chelidonium majus)
Etymologies
from Wiktionary, Creative Commons Attribution/Share-Alike License
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Examples
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(C) The Bcl-xL region shown to bind chelerythrine is highlighted while the remaining protein structure is transparent.
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The didecyldimethylammonium bromide binding site (A) is found in a region responsible for needle formation while the chelerythrine binding site (B) is found on the opposite face. doi: 10.1371/journal. pone.0007442.g004
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This issue may be minimized or eliminated by simply improving the PrgI binding affinity for chelerythrine derivatives.
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Verification that the Bcl-xL inhibitor chelerythrine also binds PrgI.
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The initial identification of the conserved DDAB ligand binding site between Bcl-xL and PrgI was used to predict, test and confirm that chelerythrine binds PrgI in a similar manner to Bcl-xL.
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A comparison between the free and chelerythrine bound PrgI 2D
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It is paramount to note that this similarity in chelerythrine binding between the two proteins would have not been discovered if it was not for the identification of the initial conserved ligand binding site between PrgI and Bcl-xL using the FAST-NMR method in combination with the CPASS database.
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Two compounds, chelerythrine and sanquinarine were identified as having affinity to Bcl-xL and were both available from commercial suppliers.
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This active-site similarity was then used to verify that chelerythrine, a known Bcl-xL inhibitor, also binds PrgI.
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(blue) illustrating the structural similarity of the chelerythrine binding sites.
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