from Wiktionary, Creative Commons Attribution/Share-Alike License.
- noun medicine
treatmentof a tumourwith a medicationin order to make it more susceptibleto radiationtreatment
from Wiktionary, Creative Commons Attribution/Share-Alike License
The sensitization effect of certain substances with regard to other chemicals - referred to as the chemosensitization effect by scientists - does not play a role in the current legislation.
The CK2 protein expression levels were determined and the effect of its down-regulation on chemosensitization of pancreatic cancer cells was investigated.
Our results demonstrate that in p53-deficient human gastric cancer cells, restoration of functional miR-34 inhibits cell growth and induces chemosensitization and apoptosis, indicating that miR-34 may restore p53 function.
Finally, our studies suggest a molecular link between the inhibition of GRP78 / BIP and E2F1-mediated chemosensitization of tumor cells, underscoring its relevance for cancer treatment.
Interestingly, AGS KD cells transfected with si p53 were significantly less susceptible to growth inhibition by 5-FU than AGS KD cells transfected with control siRNA (siRNA silencing of p53 reverses the chemosensitization of AGS KD cells.