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Examples
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Slide 3: Human AML LSCs (CD34+ / CD38 -) in NOG model: 1. home to the endosteal niche of the bone marrow; 2. win "engraftment competition" with normal hematopoietic stem cells; 3. rest in G0 cell cycle phase; 4. more likely this mechanism explains why LSCs are chemotherapeutically resistant and cause AML relapse
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