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Examples
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INT-747 (obeticholic acid) is a potent, first-in-class FXR agonist that is a small molecule bile acid derivative of chenodeoxycholic acid (CDCA), a primary human bile acid and natural endogenous FXR agonist.
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These findings suggest that FXR, when activated by chenodeoxycholic acid (a bile acid) or GW4064 (a synthetic), can slow the proliferation of breast cancer cells that are tamoxifen resistant, said one of the study's authors, Cinzia Giordano.
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INT-747 (obeticholic acid) is a potent, first-in-class FXR agonist that is a small molecule bile acid derivative of chenodeoxycholic acid (CDCA), a primary human bile acid and natural endogenous FXR agonist.
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Steppie was able to get Tina and her relatives back on the medication, chenodeoxycholic acid.
SplicedFeed 2010
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The research team activated FXR with either a bile acid, chenodeoxycholic acid, or a synthetic, GW4064.
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INT-747 (obeticholic acid) is a potent, first-in-class FXR agonist that is a small molecule bile acid derivative of chenodeoxycholic acid (CDCA), a primary human bile acid and natural endogenous FXR agonist.
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INT-747 is a potent, first-in-class farnesoid X receptor (FXR) agonist derived from the primary human bile acid chenodeoxycholic acid (CDCA), the natural endogenous FXR agonist.
Medindia Health News 2010
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Sigma-Tau has received an Orphan Drug Designation from the FDA for the use of CDCA and also has acquired the German approved chenodeoxycholic acid product called Chenofalk®.
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Sigma-Tau is pursuing US Food and Drug Administration (FDA) approval for the use of chenodeoxycholic acid (CDCA) in patients with a disease called Cerebrotendinous Xanthomatosis
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Pre-PEBD bile from AGS patients had greater chenodeoxycholic / cholic acid (CDCA / CA), bile salt, cholesterol and phospholipid concentrations than PFIC patients.
BioMed Central - Latest articles Marc E Elias Karan M Emerick 2008
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