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- noun An
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In October 2002, we submitted a regulatory application to the UK Medicines Control Agency (MCA) for Lapdap (chlorproguanil/dapsone) for the treatment of the most life threatening type of the malaria.
Mwapasa V, Purfield A, Rogerson SJ, Molyneux ME, et al. (2005) Mutations associated with sulfadoxine-pyrimethamine and chlorproguanil resistance in
Nduati E, Mberu EK, Hopkins Sibley C, Monks SA, et al. (2000) Molecular evidence of greater selective pressure for drug resistance exerted by the long-acting antifolate Pyrimethamine/Sulfadoxine compared with the shorter-acting chlorproguanil/dapsone on Kenyan Plasmodium falciparum.
Dzinjalamala FK, Kamwendo DD, Malkin EM, Cortese JF, et al. (2002) Molecular markers for failure of sulfadoxine-pyrimethamine and chlorproguanil-dapsone treatment of Plasmodium falciparum malaria.
Infants aged 8-16 weeks were randomly assigned to sulfadoxine plus pyrimethamine, chlorproguanil plus dapsone, mefloquine, or placebo-given at the second and third immunisations for measles.
(- 6•7%,) nor chlorproguanil-dapsone (10•8%) had a (statistically significant) protective effect.