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- noun Plural form of
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Lab-dish tests were also carried out on cholangiocytes - cells found in the lining of bile ducts - taken from engineered mice.
We conclude that inducible ANXA2 expression in cholangiocytes may play a compensatory role for the impaired AE activity of cholangiocytes in PBC in terms of bicarbonate-rich ductular secretion and bile formation through modulation of the PKC activity.
We revealed the upregulation of annexin A2 (ANXA2) in cholangiocytes in primary biliary cirrhosis (PBC) by a proteomics approach and evaluated its physiological significance.
Additional analysis of the effects of artificially increasing and decreasing the expression of miR15a in cholangiocytes from PKC rats and normal rats, respectively, led the authors to conclude that suppression of miR15a contributes to the development of cysts in the liver through dysregulation of Cdc25A.
The authors analyzed changes in the expression of recently identified regulatory RNA molecules known as microRNAs (miRNAs) in a cell line generated from bile duct cells known as cholangiocytes from PKC rats, a model of ARPKD.
One specific miRNA caught their eye, miR15a, as its expression was substantially decreased in these cells compared with cholangiocytes from normal rats.
- inducible gene in cholangiocytes that could serve as a potential histological marker of inflammatory cholangiopathy, including PBC.