ciliogenesis

Moreover, knockdown of modulators that are involved in the endocytic recycling pathway affected the formation of the PPC as well as ciliogenesis.

Naturejobs - All Jobs Joon Kim 2010

The screen identified 36 positive and 13 negative ciliogenesis modulators, which include molecules involved in actin dynamics and vesicle trafficking.

Naturejobs - All Jobs Joon Kim 2010

Our results uncover a critical regulatory step that couples actin dynamics and endocytic recycling with ciliogenesis, and also provides potential target molecules for future study.

Naturejobs - All Jobs Joon Kim 2010

Further investigation demonstrated that blocking actin assembly facilitates ciliogenesis by stabilizing the pericentrosomal preciliary compartment (PPC), a previously uncharacterized compact vesiculotubular structure storing transmembrane proteins destined for cilia during the early phase of ciliogenesis.

Naturejobs - All Jobs Joon Kim 2010

PCP in mouse, unlike what has been implicated in other vertebrate species, is not required for ciliogenesis, cilium motility, Sonic hedgehog (Shh) signalling or apical docking of basal bodies in ciliated tracheal epithelial cells.

Naturejobs - All Jobs Hai Song 2010

Here we report the results of a functional genomic screen using RNA interference (RNAi) to identify human genes involved in ciliogenesis control.

Naturejobs - All Jobs Joon Kim 2010

Cell growth was monitored following metabolic activity as detailed in We subsequently confirmed that ciliogenesis defects observed in βarr2-depleted cells are correlated with cell cycle dysregulation.

PLoS ONE Alerts: New Articles Anahi Molla-Herman et al. 2008

Interestingly, βarr2 was found to interact and colocalize with 14-3-3 proteins and Kif3A, two proteins known to be involved in ciliogenesis and intraciliary transport.

PLoS ONE Alerts: New Articles Anahi Molla-Herman et al. 2008

Our results strikingly paralleled those reported on Polaris, a protein found at the centrosome in cycling cells, which is involved in intra-ciliary transport and required for ciliogenesis.

PLoS ONE Alerts: New Articles Anahi Molla-Herman et al. 2008

"This really suggests that at least in Xenopus, FoxJ1 is a master-regulator of ciliogenesis and doesn't just play a role in basal body docking," says Stubbs.

Medlogs - Recent stories 2008