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- noun A particular
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Even then, however, the team had to solve another problem, which is the propensity for small-molecule drugs, such as clemizole, to get absorbed into the silicone of the chip itself.
Should clemizole prove effective in human trials, Glenn said, it could become an essential component in a new class of multidrug treatments for hepatitis C. Other components could be drugs under development elsewhere that target specific enzymes in the virus.
In all, the team found 18 drugs that substantially reduced NS4B binding to its target RNA, but they focused on clemizole because it is already known to be safe in humans.
In fact, the small team was able to screen more than 1,200 drug candidates and find clemizole in just two weeks,
The other is that the former anti-itching drug clemizole hydrochloride could hinder that protein, resulting in a tenfold decrease in virus replication with no apparent harm to infected liver-like cells.