co-stimulatory love

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Examples

  • Fernando Vieira, M.D. Specifically, the report entitled, "From transcriptome analysis to therapeutic anti-CD.0L treatment in the SOD. model of amyotrophic lateral sclerosis," details the characterization of the co-stimulatory pathway, which is a key regulator of immune system response, and the development of ALS TD. 00846 as a therapeutic biologic.

    The Earth Times Online Newspaper

  • Because we could slow the disease, at least in the mice, when we blocked the co-stimulatory pathway with ALS TDI 00846, we believe that we have implicated an immune process that may drive the degeneration of neurons.

    The Earth Times Online Newspaper

  • Because we could slow the disease, at least in the mice, when we blocked the co-stimulatory pathway with

    THE MEDICAL NEWS

  • Specifically, the report entitled, "From transcriptome analysis to therapeutic anti-CD40L treatment in the SOD1 model of amyotrophic lateral sclerosis," details the characterization of the co-stimulatory pathway, which is a key regulator of immune system response, and the development of ALS TDI 00846 as a therapeutic biologic.

    Medindia Health News

  • One potential explanation for this difference is that the ability of vhs to antagonize NF-kB-dependent genes (IL-6, TNF-α) may be separate from its ability to block IFN-dependent events (co-stimulatory molecule up-regulation).

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  • Demangel et al found that bone marrow-derived DCs that were infected with BCG showed increased expression/production of MHC class II antigens, co-stimulatory molecules and immune regulatory cytokines.

    PLoS ONE Alerts: New Articles

  • The functional difference may be related to their expression of co-stimulatory molecules and cytokine production patterns.

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  • BCG immunization induced the expansion of CD8+ DC which expressed higher levels of co-stimulatory molecules compared with CD8

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  • Since the function of DC in modulating immune responses is largely dependent on their expression of co-stimulatory molecules and the production of cytokines, we further analyzed the surface markers on the DC subsets by three-color staining (CD11c, CD8 and a particular surface marker).

    PLoS ONE Alerts: New Articles

  • Therefore, the difference in immune responses generated by the adoptive transfer of the DC subsets observed in our study is more likely reflecting a functional difference of the subsets in activating/modulating T cell responses rather than their difference in handling the microbes/antigens, especially considering the dramatic difference of the DC subsets in the expression of co-stimulatory molecules and the production of immunoregulatory cytokines.

    PLoS ONE Alerts: New Articles

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