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Examples
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Aspen has licences to the generics of combivir, AZT and 3TC and access to the generics for the patents over Zerit and Videx.
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Due to trademarks between gilead earnings atripla and lamivudine, emtriva should preferably register maintained with available concerns selecting lamivudine, postmarketing combivir (lamivudine/zidovudine), epivir or epivir-hbv (lamivudine), epzicom (abacavir sulfate/lamivudine), or trizivir
Wii-volution 2010
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Abbreviations: AZT, zidovudine; 3TC, lamivudine; CBV, combivir; CI, confidence interval; HAART, highly active antiretroviral therapy; IQR, interquartile range;
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Preliminary results from this study contributed to a change in clinical practice for the care of pregnant women with HIV; in 2004 the World Health Organisation guidelines introduced a short course of combivir with nevirapine for the management of pregnant HIV-infected women.
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The two nevirapine plus combivir arms were continued.
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A reduction was also seen in new NNRTI resistant mutations in the HIV-infected infants that received combivir.
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The women and their newborn babies were randomly assigned to receive, either (i) a single dose of nevirapine, (ii) a single dose of nevirapine plus combivir (zidovudine combined with lamivudine) for four days, or (iii) a single dose of nevirapine plus combivir for seven days.
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The study did not have enough women to show that there was a real difference between the resistance in the four-day and seven-day combivir regimens.
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The researchers found that selection of resistance mutations by single-dose nevirapine was reduced in mother and child by the addition of zidovudine and lamivudine for a short period; resistance mutations were found in 59. 2% of women who got nevirapine only but only 11. 7%, and 7. 3% of women treated nevirapine plus four days combivir, and nevirapine plus seven days combivir respectively.
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The primary objective of this trial-the Treatment Options Preservation Study (TOPS) - was to compare the selection of maternal NNRTI resistance mutations after receipt of three NVP-containing regimens for prevention of mother-to-child transmission (PMTCT): sdNVP alone or sdNVP combined with short courses (either 4 or 7 d) of AZT and lamivudine (3TC), given as combivir, initiated simultaneously with the dose of NVP at the onset of labour to mother and continued postpartum.
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