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  • The disease form in early infancy is referred to as connatal PMD and diagnosis in later childhood is most typically associated with the classic form.

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  • Simply this -- that all necessity for supposing immediate impressions made upon our understandings by God, or other supernatural, or antenatal, or connatal, agencies, is idle and romantic; for that, upon examining the furniture of our minds, nothing will be found there which cannot adequately be explained out of our daily experience; and, until we find something that cannot be solved by this explanation, it is childish to go in quest of higher causes.

    The Uncollected Writings of Thomas de Quincey—Vol. 1 With a Preface and Annotations by James Hogg

  • Those with the most severe form of the disease, connatal PMD, lose the ability to walk and talk and eventually die, often before the age of 10.

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  • The term congenital peculiarity, I may remark, is a loose expression and can only mean a peculiarity apparent when the part affected is nearly or fully developed: in the Second Part, I shall have to discuss at what period of the embryonic life connatal peculiarities probably first appear; and I shall then be able to show from some evidence, that at whatever period of life a new peculiarity first appears, it tends hereditarily to appear at a corresponding period {192}.

    The Foundations of the Origin of Species Two Essays written in 1842 and 1844


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