corazonin

So, while it is recognized that corazonin is a highly conserved neuropeptide throughout the insects, a unifying theme to connect these different functions associated with corazonin has been lacking., cells that express corazonin also express receptor molecules for two unrelated diuretic hormones, DH

PLoS ONE Alerts: New Articles Yan Zhao et al. 2010

We also note that the demonstration of corazonin neuron involvement within stress response behaviors is paralleled by previous observations describing suppression of GnRH (suspected corazonin homolog, by virtue of receptor similarities) release as part of the stress response in mammals, by virtue of its modulation of stress hormones Model of corazonin neuronal function in Drosophila.

PLoS ONE Alerts: New Articles Yan Zhao et al. 2010

If this is the case with corazonin neurons, this would suggest that there are fundamental differences in corazonin circuits between males and females, and may explain the differences we have observed utilizing this experimental strategy.

PLoS ONE Alerts: New Articles Yan Zhao et al. 2010

These results underscore the importance of central peptidergic processing within the context of stress and place corazonin signaling as a critical feature of neuroendocrine events that shape stress responses and may underlie the inherent sexual dimorphic differences in stress responses.

PLoS ONE Alerts: New Articles Yan Zhao et al. 2010

The corazonin neuropeptide was originally discovered based on its potent cardioacceleratory actions in the cockroach,

PLoS ONE Alerts: New Articles Yan Zhao et al. 2010

In contrast, there is apparently a lack of corazonin dependence in determining normal activity levels in females.

PLoS ONE Alerts: New Articles Yan Zhao et al. 2010

In males, the loss of corazonin signaling produced phenotypes similar to those with the silencing of corazonin neurons, and as expected, the activation of corazonin neurons consistently produced opposite phenotypes.

PLoS ONE Alerts: New Articles Yan Zhao et al. 2010

Notably, the connection between dopamine and GnRH signaling in the vertebrates is well-documented [e.g., 55] and lends additional support for functional parallels between mammalian GnRH and insect corazonin signaling.

PLoS ONE Alerts: New Articles Yan Zhao et al. 2010

We reasoned that the alterations in lifespan exhibited in flies differing in corazonin neuronal function may, in part, stem from changes in activity levels as activity may correlate with stress-sensitivity.

PLoS ONE Alerts: New Articles Yan Zhao et al. 2010

To gauge relative expression of the corazonin transcript, we normalized levels to those ascertained for

PLoS ONE Alerts: New Articles Yan Zhao et al. 2010