Definitions

from The American Heritage® Dictionary of the English Language, 4th Edition

  • n. A substance that combines with and activates a genetic repressor, thus preventing gene transcription and inhibiting protein synthesis.

from Wiktionary, Creative Commons Attribution/Share-Alike License

  • n. Any substance that reacts with a genetic repressor in order to activate it and decrease gene expression

Etymologies

co- +‎ repressor (Wiktionary)

Examples

  • Streaker ED, Ruparelia S, Beckett D (2000) Multiple disordered loops function in corepressor-induced dimerization of the biotin repressor.

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  • Interacting role of the androgen receptor and the corepressor Alien in the proliferation inhibition of prostate cancer cells.

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  • More information: GPS2-dependent corepressor/SUMO pathways govern anti-inflammatory actions of LRH-1 and LXRb in the hepatic acute phase response, Genes

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  • The transcriptional activity of Nuclear hormone Receptors (NRs) is regulated by interaction with coactivator or corepressor proteins.

    BioMed Central - Latest articles

  • K, Ravi D. S, Mitra D. Galande S (2005) D.splacement of SATB1-bound histone deacetylase 1 corepressor by the human immunodeficiency virus type 1 transactivator induces expression of interleukin-2 and its receptor in T cells.

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  • However, at very early time points (up to 9 h upon induction of Wnt signalling), PCAF is upregulated and so is the acetylation of SATB1, leading to its dissociation from the CtBP1 corepressor

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  • Teashirt recruits the transcriptional corepressor CtBP via a PLDLS motif at the amino-terminus

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  • Two major corepressors, SMRT (silencing mediator for retinoid and thyroid hormone receptors) and N-CoR (nuclear receptor corepressor), have been shown to mediate repression associated with nuclear receptors and a myriad of other transcription factors.

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  • The successful applicant will use a combination of molecular biology, Drosophila genetics and bioinformatics to study the molecular mechanisms used by the Groucho corepressor to regulate gene expression during animal development.

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  • We observed that the proteins silencing mediator for retinoid and thyroid hormone receptor (SMRT) and the nuclear receptor corepressor

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