from The American Heritage® Dictionary of the English Language, 4th Edition

  • n. Genetics A hybrid vector that has been spliced with plasmid DNA for cloning large genes or gene fragments.

from Wiktionary, Creative Commons Attribution/Share-Alike License

  • n. A type of plasmid (often used as a cloning vector) constructed by the insertion of cos sequences, which are DNA sequences of the lambda phage.

from WordNet 3.0 Copyright 2006 by Princeton University. All rights reserved.

  • n. (genetics) a large vector that is made from a bacteriophage and used to clone genes or gene fragments


Blend of cos (sequence), sequence of DNA allowing the cosmid to form as a circle (short for cohesive ends) and plasmid.
(American Heritage® Dictionary of the English Language, Fourth Edition)
Blend of cos and plasmid (Wiktionary)


  • E. coli and 25 µg/ml for M. smegmatis; and hygromycin B, 100 µg/ml for oppA (Rv1280c) of M. tuberculosis was amplified from cosmid MTCY50 using the primer pair

    PLoS ONE Alerts: New Articles

  • The alphaT2ib open reading frame was integrated into an adenoviral cosmid vector for production of recombinant adenovirus (AdV) - alphaT2ib.

    BioMed Central - Latest articles

  • However, the linearized cosmid produced an incomplete assembly because the two DNA termini, though greatly over-represented in the clone library used for sequencing, were separated from neighboring sequences by gaps of ~1. 4 and 1.8 kb.

    BioMed Central - Latest articles

  • These gap sizes were reduced, but not eliminated, by shearing the linear cosmid into smaller fragments.

    BioMed Central - Latest articles

  • 1987 (Burke et al. 1987) permitted much larger segments of DNA to be ordered and stored for sequencing than was possible with plasmid or cosmid libraries.

    The Human Genome Project


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