cross-presentation love

cross-presentation

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Examples

  • +DC to present exogenous antigens through a process of cross-presentation

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  • Schnorrer P, Behrens GM, Wilson NS, Pooley JL, Smith CM, et al. (2006) The dominant role of CD8+ dendritic cells in cross-presentation is not dictated by antigen capture.

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  • The presentation of this peptide on class I molecules by human melanoma cells required a cross-presentation mechanism.

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  • Altogether these results identify a novel mechanism underlying selective tumor cell recognition through cross-presentation of a post-translationally modified ubiquitous protein.

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  • We showed that recognition of melanoma cells by this CTL clone required MMP-2 secretion and cross-presentation of the HLA-A2-restricted MMP-2

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  • Hypothetical models for MMP-2560-568 epitope generation by cross-presentation and by endogenous pathway.

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  • In spite of MMP-2 classified as a self-antigen, the fact that cross-presentation is the only way to present this MMP-2 epitope underlines the importance to target this type of antigen in immunotherapy protocols.

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  • Godefroy E, Moreau-Aubry A, Diez E, Dreno B, Jotereau F, et al. (2005) alpha v beta3-dependent cross-presentation of matrix metalloproteinase-2 by melanoma cells gives rise to a new tumor antigen.

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  • The presentation of this peptide on class I molecules by human melanoma cells required a cross-presentation mechanism.

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  • Fig. 6 a model explaining why the MMP-2 epitope is normally presented only through the cross-presentation pathway.

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