Definitions

from Wiktionary, Creative Commons Attribution/Share-Alike License

  • n. A naturally-occurring alkaloid that belongs to the group of steroidal jerveratrum alkaloids and has the molecular formula C27H41NO2

Etymologies

from Wiktionary, Creative Commons Attribution/Share-Alike License

Blend of cyclops and amine. So called for its ability to induce cyclopia in certain animals.

Examples

  • Interesting research is being done on a chemical called cyclopamine, derived from the corn lily plant.

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  • The inhibition of sonic hedgehog signaling with cyclopamine caused hypomorphic limbs (during development and regeneration) but did not affect the expression of BMP-2 and SOX-9.

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  • Kim SK, Melton DA (1998) Pancreas development is promoted by cyclopamine, a hedgehog signaling inhibitor.

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  • However, preliminary results indicate that blocking SHH signaling with cyclopamine at different time-points have no impact on the appearance of

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  • On various different time-points, cyclopamine (Sigma) was used in a concentration of 0.25 ┬ÁM in order to inhibit shh.

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  • Taipale J, Chen JK, Cooper MK, Wang B, Mann RK, et al. (2000) Effects of oncogenic mutations in Smoothened and Patched can be reversed by cyclopamine.

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