Definitions
from Wiktionary, Creative Commons Attribution/Share-Alike License
- n. A polycyclic alkaloid whose pharmacological activity is similar to nicotine; used in the treatment of nicotinism.
Etymologies
Examples
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Their success is down to the active ingredient cytisine, which is derived from laburnum seeds.
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CHANTIX was modeled after a natural substance called cytisine that occurs in legumes and other plant substances.
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The smoking-cessation drug Chantix varenicline is a derivative of cytisine.
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In experiments with mice, cytisine prevented weight gain by activating the same set of neurons in the hypothalamus as nicotine does.
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Mineur, an associate research scientist in psychiatry at Yale School of Medicine, stumbled upon the compound used in the study, cytisine, while looking into possible drugs for depression.
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Researchers at Yale University found that low doses of nicotine or cytisine, a drug that binds to nicotine receptors, reduced body fat in mice by 15% to 20% and food intake by up to 50% but had no effect on water consumption.
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When mice with the POMC pathway were given nicotine or cytisine, they lost weight whereas mice without the pathway were unchanged.
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But when it comes to weight, the Yale research found that both nicotine and the related drug cytisine were activating a different receptor than the one involved in addiction.
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The other drug used in the mouse experiments, cytisine, is sold in Eastern Europe for smoking cessation but not in the U.S., and she'd like to see if there's data on the weight of smokers abroad who've used it.
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Schroeder said if people in a trial of cytisine were to receive as much counseling as they do in trials of other drugs, such as Zyban and Chantix, and if treatment was longer, then similar quit rates of 15 to 25 percent would be seen.
Comments
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