cytotrophoblastic

We also demonstrated increased levels of Bcl-2 and Bcl-xL in cytotrophoblastic cells treated with vitamins C and E at standard culture conditions.

PLoS ONE Alerts: New Articles Tai-Ho Hung et al. 2010

Increased Bcl-2 and Bcl-xL and decreased LC3-II in cytotrophoblastic cells treated with vitamins C and E at standard culture condition

PLoS ONE Alerts: New Articles Tai-Ho Hung et al. 2010

Changes in Bcl-2, Bcl-xL and mitochondrial Bax, and Bak in cytotrophoblastic cells.

PLoS ONE Alerts: New Articles Tai-Ho Hung et al. 2010

Bcl-2 and Bcl-xL and an increase in the mitochondrial Bak protein levels were noted in cytotrophoblastic cells treated with vitamins C and E at HR in comparison to the vehicle control.

PLoS ONE Alerts: New Articles Tai-Ho Hung et al. 2010

Our study showed that concomitant administration of vitamins C and E increased apoptotic changes in villous explants and cytotrophoblastic cells under HR.

PLoS ONE Alerts: New Articles Tai-Ho Hung et al. 2010

In contrast, the relative amount of LC3-II was increased in cytotrophoblastic cells treated with vitamins C and E at HR. (b, d) However, there were no differences in the levels of LC3-I and beclin-1 between the vehicle control and vitamin treatment groups at either standard culture conditions or HR.

PLoS ONE Alerts: New Articles Tai-Ho Hung et al. 2010

Furthermore, increased levels of Bcl-2 and Bcl-xL in association with a decrease in the autophagy-related protein LC3-II were noted in cytotrophoblastic cells treated with vitamins C and E under standard culture conditions.

PLoS ONE Alerts: New Articles Tai-Ho Hung et al. 2010

In addition to allowing regeneration of syncytiotrophoblast and investigating chronic regulation of apoptosis and autophagy, another reason for us to incubate villous explants and cytotrophoblastic cells under normoxia or HR for 48 hours before administration of vitamins C and E is to precondition the trophoblast cells with our experimental settings.

PLoS ONE Alerts: New Articles Tai-Ho Hung et al. 2010

Therefore, we feel that preconditioning the villous explants or cytotrophoblastic cells to HR for a period before administration of vitamins C and E is important in investigating the effects of these antioxidant vitamins.

PLoS ONE Alerts: New Articles Tai-Ho Hung et al. 2010

Decreased Bcl-2 and Bcl-xL and increased mitochondrial Bak and cytosolic LC3-II in cytotrophoblastic cells treated with vitamins C and E at HR

PLoS ONE Alerts: New Articles Tai-Ho Hung et al. 2010