Definitions
from Wiktionary, Creative Commons Attribution/Share-Alike License.
- noun biochemistry Any of several classes of
enzyme that removeacetyl groups fromproteins
Etymologies
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Examples
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After exploring the biological mechanism behind the improvement in mice placed in the enriched environment, the researchers tested on the mice a class of drugs called histone deacetylase, or HDAC, inhibitors.
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Scientists then tested a class of drugs called histone deacetylase, or HDAC, inhibitors on the mice.
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A group of agents called histone deacetylase inhibitors can help here, says Sharon Lewin, director of the infectious-diseases unit at Alfred Hospital in Melbourne, who is about to start a clinical trial of a histone-deacetylase inhibitor called SAHA.
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These cells were strongly sensitized to APO010 by pretreatment with ionizing - or UV radiation, etoposide, histone deacetylase - or proteasome inhibitors.
Naturejobs - All Jobs I Verbrugge 2010
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We are currently developing inhibitors of histone deacetylase 3 (HDAC-3) for the treatment of inherited neurodegenerative diseases such as Friedreich's ataxia.
TradingMarkets 2010
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Histone deacetylase Inhibitor, PCI-24781, is the company's orally-bioavailable HDAC Inhibitor that disrupts DNA repair and contributes to tumor cell death.
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Histone deacetylase 8 Inhibitor, PCI-34051, is at the preclinical lead optimization stage.
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He described the success of a drug called Zolinza, which takes the brakes off silenced genes by inhibiting a type of enzyme called histone deacetylase (HDAC); Zolinza was bought by Merck for an estimated $145 million in 2004, and was approved to treat cutaneous T-cell lymphoma the year before.
News from The Scientist Alla Katsnelson 2010
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These drugs included proteasome inhibitors, histone deacetylase inhibitors, along with inhibitors of molecules called NFĸB and Sp1.
PhysOrg.com - latest science and technology news stories 2010
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Table 8 Histone deacetylase agents in anticancer development
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