deacetylases

Definitions

from Wiktionary, Creative Commons Attribution/Share-Alike License.

  • noun Plural form of deacetylase.

Etymologies

Sorry, no etymologies found.

Examples

  • Sirtuins are a substance that the scientifically observant elite have particular type of enzymes known as deacetylases, identified as resveratrol, a phytonutrient originating - in which function to remove acetyl groups (CH3CO -) this case - in the vinyards.

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  • The researchers found that blocking histone deacetylases HDACs, enzymes that remove part of a histone which also trigger anxiety, reduces anxiety during alcohol withdrawal.

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  • Histones are proteins that regulate DNA packing, and histone deacetylases are enzymes that control the way those proteins work.

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  • Pancani T, Formentini L, Mascagni P, Fossati G, et al. (2006) Pharmacological inhibition of histone deacetylases by suberoylanilide hydroxamic acid specifically alters gene expression and reduces ischemic injury in the mouse brain.

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  • Emiliani S, Verdin E, Webb Y, Breslow R, et al. (1998) A class of hybrid polar inducers of transformed cell differentiation inhibits histone deacetylases.

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  • Enzymes, such as histone deacetylases (HDAC) or methyltransferases (HMT) can change the modification of the histone tails and therefore change the 'histone code'.

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  • The cancer targets were chosen for their potential of mechanistic synergy and include class I and II histone deacetylases, or HDACs, EGFR and Her2.

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  • It is thought that the antiepileptic activity of VPA results from a combination of its influence on a number of targets in the central nervous system including inhibition of GABA transamination, reduction of NMDA-mediated neuronal excitation, inhibition of histone deacetylases (HDACs) and glycogen synthase kinase (GSK) -3, and blockade of voltage-gated sodium and T-type calcium channels

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  • The cancer targets were chosen for their potential of mechanistic synergy and include class I and II histone deacetylases, or HDACs, EGFR and Her2.

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  • Valproate, a widely used antiepileptic drug, has a number of targets including GABA transaminase, voltage-gated sodium channels, glycogen synthase kinase (GSK) -3, and histone deacetylases (HDACs), and therefore may attenuate a number of TBI-associated pathologies.

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